Insilico MedicineInsilico Medicine Longevity Grok
Setup prompt copied. Paste it into your Grok Bot. Open Grok Bot ↗
PLSI · Personal Longevity Superintelligence

Your personal longevity research team

Longevity Grok is a team of AI agents on Grok Bot, led by PLSI, your Personal Longevity Superintelligence. It keeps your labs, wearables and plans in one place, researches the questions that matter to your goals, and prepares your visits with physicians you already trust. If you choose, it can also help the whole field learn faster.

Get started Watch the walkthrough
Your Longevity Grok teamYou and PLSI at the centre, surrounded by the eight core bots, with specialists, your physician and the optional MotherShip on the outer ring. Data Manager Health Analyst Forecaster Challenger Progress Reviewer Privacy Guard Eraser Visualizer Device Technician Nutritionist Longevity Coach Sleep Coach Research Curator Your physician MotherShip You + PLSI Chief Orchestrator

Core teamSpecialists you pickOptional, opt-in

The Four Laws of Longevity AI

Every Longevity Grok agent follows these laws, in this order: a lower law never overrides a higher one.

1

Do no harm

Nothing PLSI suggests, records or sends may hurt the user or anyone else: screen every action, name the risks, act on red flags first, and when the evidence is unclear, say so and do less.

2

Extend the user's healthy life

With measured, predicted and honestly scored steps toward their own goals.

3

Extend the community's healthy life

Every user is also a citizen scientist: help longevity science move faster for everyone by running research with spare credits, pooling findings and de-identified data with others through the Longevity MotherShip, and bringing back what the community has learned. What the user shares stays their choice and never identifies them.

4

Never stop until aging is under control

Keep delivering measurable progress in research, targets, biomarkers and education, for as long as it takes, until aging is under control for everyone who wants that help.

Get started

The most important part: onboard your Grok Bot in three steps. It does most of the setup for you.

1

Get Grok Bot

Longevity Grok runs inside Grok Bot, xAI's platform for persistent AI agents. Sign up for an account first.

Get Grok Bot ↗
2

Add Longevity Grok

Tell your Grok Bot to follow plsi.md from the open repository. It installs everything and builds your team in about ten minutes.

Open plsi.md →
3

Choose your role

PLSI, your Chief Orchestrator, asks during setup.

Everyone starts here: your health record, scored plans, research briefs and visit prep. Available now

Paste this into your Grok Bot
Set up Longevity Grok for me: follow plsi.md from https://github.com/Insilico-org/plsi

By installing, you agree to the Terms of Service.

For developers: install from the command line

Install the client from Insilico-org/plsi. MotherShip contracts and the relay live in Insilico-org/plsi-mothership. Always follow the README in the repository for the latest steps.

python -m venv .venv && . .venv/bin/activate
python -m pip install -e ".[dev]"        # add ,clocks for methylation clocks
plsi doctor
plsi init --instance me --birth-year 1970 --sex F
plsi ingest --instance me --csv labs.csv --dry-run
plsi ingest --instance me --csv labs.csv
plsi maps select --instance me
plsi project --instance me --map blood_phenoage
plsi report  --instance me --map blood_phenoage
plsi role set individual                 # or physician / researcher

Lab CSV header: effective_at,text,value,unit[,code_system,code,specimen,kind,fasting]. Optional keys go in a git-ignored .env (copy .env.example). Join or leave sharing with plsi mothership join / status / leave.

LayerPackageWhat it does
Lifeplsi.lifeIntake (FHIR, CSV, methylation, Grok-extracted JSON), code normalisation, append-only event log.
Mapplsi.mapMap registry, selector and mapper; derived coordinates and state documents.
Policyplsi.policyEvidence search and verification, screening, plan gates, scoring and calibration.

See it in action

Ask one question and a whole team goes to work. Here is what happens, step by step.

A narrated screen recording of a real Longevity Grok session, about nine minutes.

You“I sleep badly and wake up at 4 am. What can I try?”
PLSI · Chief OrchestratorHands the question to the right bots
Data ManagerYour health record
Device TechnicianSleep data from your watch
Health AnalystWhat has changed
Sleep CoachSleep and stress options
Longevity CoachExercise options
ForecasterOne safety-screened plan with predictions
ChallengerStress-tests every step
VisualizerDraws your trajectory
PLSI to you

Your plan · 2 experiments · example

Sleep: lights out by 23:00 → predicted: more deep sleep in 6 weeks
Activity: 3 × 30 min zone-2 walks a week → predicted: fewer early wake-ups
Adopt planNot now
Progress ReviewerSix weeks later: scores each prediction

Your team: 30 bots

PLSI · Chief OrchestratorYour Personal Longevity Superintelligence. You talk only to PLSI; it runs the 29 bots below for you. The core team is always on, you pick the specialists, and Clinic and Lab come with the physician and researcher roles.
  • Core teamAlways on, for everyone
  • Core
    Data Manager

    Turns your records, history and updates into one organised health record.

  • Core
    Health Analyst

    Explains your results, highlights changes and spots missing measurements.

  • Core
    Forecaster

    Merges the specialists' ideas into one safety-screened plan with predictions.

  • Core
    Challenger

    Looks for weak evidence, risks and contradictions in every plan.

  • Core
    Progress Reviewer

    Checks whether an adopted plan is working against its predictions.

  • Core
    Privacy Guard

    Checks everything against your privacy rules before it leaves your computer.

  • Core
    Eraser

    Deletes your data only when you ask, and offers you a copy first.

  • Core
    Visualizer

    Turns results, forecasts and reviews into charts and dashboards.

  • SpecialistsYou pick, and can add or remove any later
  • Specialist
    Device Technician

    Connects wearables and health apps.

  • Specialist
    Nutritionist

    Food logs and diet options backed by evidence.

  • Specialist
    Longevity Coach

    Exercise, smoking and alcohol.

  • Specialist
    Sleep Coach

    Sleep and stress.

  • Specialist
    Biohacker

    Supplements and the evidence behind them.

  • Specialist
    Research Curator

    New longevity studies and your research digest.

  • Specialist
    Citizen Researcher

    Your longevity questions, written up as research notes.

  • Specialist
    Research Autopilot

    Works one research question a little every day.

  • Specialist
    Care Navigator

    Physicians, clinics and local activities.

  • Specialist
    Trial Scout

    Clinical trials that may fit you.

  • Specialist
    Biotech Analyst

    Pharma and biotech companies. Research, not investment advice.

  • Specialist
    Systems Engineer

    New importers and calculations, with your approval.

  • Specialist
    Science Writer

    Reports and manuscript drafts.

  • Choose yours during setup

    PLSI preselects the recommended specialists for your goals. Add or remove any of them later, just by asking.

    Get started →
  • ClinicFor physicians
  • Clinic
    Patient Coordinator

    Your patient list and who needs follow-up.

  • Clinic
    Visit Assistant

    Pre-visit briefs and visit notes.

  • Clinic
    Evidence Analyst

    Evidence and guidelines for tests and treatments.

  • Clinic
    Clinic Liaison

    Patient messages for your approval.

  • LabFor researchers
  • Lab
    Target Hunter

    Aging targets and drug repurposing candidates.

  • Lab
    Cartographer

    Maps a research field and who works on it.

  • Lab
    Cohort Analyst

    Preregistered analyses on MotherShip data.

  • Lab
    Grant Writer

    Grant applications and project proposals.

Insilico Medicine & David Sinclair Launch Longevity Grok: Toward Longevity Superintelligence

How it works

Your Grok Bot runs your personal Longevity Grok team, and nothing leaves it unless you opt in. If you do, de-identified data passes three checks and a privacy relay before it reaches the Longevity MotherShip, Insilico Medicine's longevity research hub.

Setup

Public GitHub repo

Skills, agent definitions, routines and access points

sync

Your Grok Bot

The install on your own account

One prompt: follow plsi.md. Setup takes about ten minutes.
Your space
PLSI · Chief Orchestratorthe one you talk to; it conducts your team
Core team · always on
Data ManagerHealth AnalystForecasterChallengerProgress ReviewerPrivacy GuardEraserVisualizer
Specialists you pick
Device TechnicianNutritionistLongevity CoachSleep CoachBiohackerResearch CuratorCitizen ResearcherResearch AutopilotCare NavigatorTrial ScoutBiotech AnalystSystems EngineerScience Writer
Clinic · for physicians
Patient CoordinatorVisit AssistantEvidence AnalystClinic Liaison
Lab · for researchers
Target HunterCartographerCohort AnalystGrant Writer

Clinic and Lab need applicant review. All 30 bots are listed under See it in action.

Airlock

Only de-identified, coded data you agreed to share.

  1. EligibilityCode removes identity and checks the format, then the Privacy Guard clears it
  2. UtilityThe Challenger checks a research note is worth sending
  3. VeracityThe MotherShip checks it again; Insilico's data stewards decide
A Cloudflare relay hides who sent it
Longevity MotherShip

Insilico Medicine's research hub. Your Longevity Grok connects to it only if you opt in.

  • StoresYour data under a contributor code
  • ReleasesCombined results, once a month
  • ReviewsFindings for verified physicians and researchers
What it's for PapersNew drugsCollaborationsBetter care

What happens when you share

Sharing is a separate choice from using Longevity Grok. These are the only four exchanges.

01

Join, once

YouRelay

You choose what to share and agree to the consent form. Longevity Grok makes a random contributor code on your computer, and your files carry that code instead of your identity.

02

Every week

YouRelayMotherShip

Longevity Grok sends at most one file of codes, numbers and units, dated to the month. The relay hands it on within a day, the MotherShip checks it again and refuses anything that shouldn't be there, and you get a receipt.

03

If you leave

YouRelayMotherShip

Stop sharing any time, or ask for everything to be deleted. A secret only your Longevity Grok holds proves it's you, deletion is automatic, and you get a receipt.

04

Research notes

Your emailMotherShip

Your Citizen Researcher writes a note and the Challenger checks it's worth sending. It goes from your own Grok email, not the relay, and an Insilico reviewer decides.

Who knows what

Your Longevity Grok

Everything about you, and the secret behind your contributor code.

Relay

Your internet address while you are connected (no logs) and which kind of file you sent. Never which code is yours.

MotherShip

Your contributor code and what you shared. Never your internet address or your name.

The Longevity MotherShip

Insilico Medicine's longevity research hub. Your Longevity Grok connects to it only if you opt in.

In

Coded, de-identified data, at most once a week, and only after you join. Never your chats or anything you type.

Out

A public catalog, data releases of averages by age band and sex (groups under ten left out), and reviewed findings. Verified physicians and researchers get access.

What it does for you

Anyone with Grok Bot can run their own longevity research team: for themselves first, for the community only when they choose. It connects everyday longevity practice to Insilico-grade research, without pretending to be a clinic in a box.

“Tools into the hands of the willing. Everyone with Grok Bot can be a longevity researcher.”

Alex Zhavoronkov, founder and co-CEO, Insilico Medicine

Your longevity, organised

Labs, wearables, protocols and plans in one place, with day-to-day follow-up. Predictions are scored and checked, not guessed.

Connects withGoogle HealthApple Health via P.R.O.FatSecretLab reports

Research for you

Literature, mechanisms and open questions tied to your own goals. It stays private to you.

Physicians you already know

Visit prep and message drafts that you approve before anything is sent. Your clinician always keeps the final say.

Help the field, if you want

Optionally contribute de-identified data to the Longevity MotherShip. Sharing is off until you turn it on.

Who it's for

When you set it up, you pick a role. Everyone gets the personal longevity agents; physicians and researchers get extra tools on top. Physician and researcher tools are rolling out by invitation: request early access and the team will be in touch.

Available now

Individuals

Anyone with Grok Bot

  • One place for your labs and wearables
  • Scored plans and day-to-day follow-up
  • Research briefs tied to your goals
  • Visit prep for your physician
  • Optional sharing with the MotherShip
Get started now →
Early access

Physicians

Clinicians in longevity practice

  • Everything individuals get, plus the Clinic team
  • Patient panel and visit prep
  • Clinical evidence summaries
  • Liaison drafts that you approve
Request early access →
Early access

Researchers

Scientists, discovery and methods teams

  • Everything individuals get, plus the Lab team
  • Target hunting and research landscape
  • Cohort analysis and grant drafts
  • MotherShip collaboration when invited
Request early access →

Your first week: 5 things to ask PLSI

Copy a prompt, paste it into your chat with PLSI and watch the team work. Each one uses features that are live today.

  1. Day 1

    Get your first results explained

    Attach a blood test (PDF or photo). PLSI records it and the Health Analyst explains what it shows.

    Here are my latest blood test results. What is my blood-test age, and what could I try over the next three months to lower it?
  2. Day 2

    Connect your devices

    The Device Technician brings in sleep, activity and heart data, so you don't log anything by hand.

    Connect my Google Health so my sleep and activity are tracked automatically.
  3. Day 3

    Set up your routines

    PLSI already runs a weekly check-in. Add a research digest so new studies come to you.

    Which routines are running for me? Also turn on a weekly longevity digest on healthy sleep and heart health.
  4. Day 4

    Start your first research project

    The Research Autopilot works one question a little every day, inside the budget you set, and tells you what it found and what it could not settle. Pick it as a specialist during setup, or PLSI will offer to add it.

    Start a research topic: does magnesium improve deep sleep in people over 40? Work on it a little every day and tell me what you find.
  5. Day 5

    Get personalised advice

    Specialists propose options, the Forecaster turns them into one plan with predictions, and the Challenger tests it first.

    I sleep badly and wake up around 4 am. Based on my records, what could I try? Give me a plan I can check in 6 weeks.

Built on 15 years of longevity AI

Longevity Grok brings Insilico Medicine's work in AI for aging research, from the first deep aging clocks to today's longevity language models, into one personal companion.

Explore the research

News and how to cite

The latest from the Longevity Grok and Insilico longevity work.

  1. Longevity Grok v0.2.0 is out

    Research Autopilot for daily research on a budget you set, the new Clinic and Lab teams, new names for every bot, and MotherShip v0.2.0 with delivery receipts.

    See the release →
  2. Longevity Grok code is public

    The Longevity Grok client and MotherShip repositories went public on GitHub.

    See the repository →
  3. Cell: an open benchmark and language models for AI in aging biology

    LongevityBench, longevity language models and Longevity Claw, released openly.

    Read the paper →
  4. Nature Biotechnology: proteomic aging clocks in a phase 2a trial

    Aging clocks used inside a clinical trial of rentosertib to assess geroprotection.

    Read the paper →
  5. Longevity medicine enters medical school

    More than 13,000 medical professionals enrolled in Education Hub courses; mandatory modules in Indonesia and Thailand.

    Read the story →

How to cite

The software

Insilico Medicine. (2026). Longevity Grok: Personal Longevity Superintelligence client [Computer software]. GitHub. https://github.com/Insilico-org/plsi

LongevityBench and longevity language models

Zhavoronkov, A., Naumov, V., Sidorenko, D., Aliper, A., Aladinskiy, V., Hasani, R., Amini, A., Nasto, K., Reymond, M., Shayakhmetov, R., Miftakhutdinov, Z., Gladyshev, V. N., & Galkin, F. (2026). An open benchmark and language models for AI in aging biology. Cell, 189(19), 5980–5994. https://doi.org/10.1016/j.cell.2026.08.026

FAQ

Is Longevity Grok a doctor?

No. It's a research and education companion that helps you organise your health and prepare for visits, not a medical device. It never writes a diagnosis, a prescription or an order, and nothing replaces your clinician's judgment. In an emergency, call your local emergency services.

Where is my data kept?

In your own Grok Bot account. Longevity Grok stores your records on the computer your Grok Bot uses, and they stay there and in your Grok chats. Nothing is shared unless you opt in to share de-identified summaries of your records, research outputs, or developer feedback. Your private information, such as login credentials, is kept secret in Grok Bot's vault and is never copied into the chat.

What is the Longevity MotherShip?

A central hub governed by Insilico Medicine to promote communal research and data sharing. You may choose to share de-identified summaries of your health trajectories to help researchers fight aging, or submit your own research ideas and results to find collaborators. Joining is optional and does not affect normal Longevity Grok use.

What gets shared if I join the MotherShip?

At most once a week, the MotherShip will request the summary of your health data, such as average steps per day or exercise minutes, blood test records, medication, etc. Your age will be recorded as a five-year age bracket; your name, contact details, occupation or other identifiable features are not collected. Your health summary is sent via an anonymous relay under an encrypted pseudonym, which cannot be tracked to your Grok Bot account. All uploads to the MotherShip require your explicit approval.

Why should I trust Longevity Grok's suggestions?

Every proposal comes with clear predictions and evidence, and is tested by the Challenger agent, whose task is to critically review all information presented to you. As new information arrives, e.g. from your wearable trackers, Longevity Grok scores previous predictions, analyses the progress, and adapts the plan.

Does Longevity Grok sell anything?

No. We don't sell or advertise commercial products. Any suggestions come from evidence, your own data and preferences.

Can I stop sharing or delete my data?

Yes, at any time. Say "stop sharing with the MotherShip" and nothing more is sent. You can also ask the MotherShip to delete everything it holds under your code: deletion is automatic and you get a receipt. And you can ask PLSI to delete all your data on your own computer; it offers you a copy first.

Is Longevity Grok free?

Longevity Grok software is free and open source on GitHub (MIT licence). You need to have a Grok Bot account, however.

What do I need to start?

A Grok Bot account. Paste one prompt and your Grok Bot sets everything up in about ten minutes. See Get started.

Team and partners

The scientists, builders and educators behind Longevity Grok.

David Sinclair

Longevity Grok turns Grok Bot into an open platform where individuals, physicians, and scientists can use AI to better understand their health, predict the effects of interventions, and find ways to live longer, healthier lives.

What makes this exciting is that people can contribute to scientific discovery while improving their own health, helping us understand why we age and how we might slow or even reverse it.

Vision · Science · Leadership

David Sinclair

Scientific vision and leadership for the longevity research agenda Longevity Grok serves.

Alex Zhavoronkov

The complete longevity ecosystem, citizen scientists, longevity medicine doctors, and institutional researchers working together around the clock with frontier AI systems, has long been a personal dream. Its goal is to extend and improve life for everyone on the planet in a sustainable, maximally beneficial way, with full individual control.

Grok Bot made this possible. When infrastructure and intelligence coming from the planet’s strongest technology and engineering team, with rigorous data security, privacy, and real flexibility, meets the strongest longevity AI research teams, always-on longevity superintelligence becomes reality.

Vision · Organization · Relentless pursuit

Alex Zhavoronkov

Founder and co-CEO of Insilico Medicine. Owns the product vision, the organization, Education Hub policy, and what the project claims publicly.

Fedor Galkin
Organization · Implementation · Distribution

Fedor Galkin

Science and implementation lead. Owns the data schemas, the bots, MotherShip package delivery, and distribution of working builds.

Dominika Wilczok
Longevity Education Hub

Dominika Wilczok

Coordinates the Longevity Medicine Education Hub at longevity.degree, the education path into Longevity Grok and its physician packages.

Evelyne Eva Bischof
Longevity Education Hub

Evelyne “Eva” Bischof

Longevity medicine education and the bridge to the physician community.

Dr. Fah Wanviput
Curriculum lead, KMITL Thailand

Dr. Fah Wanviput

Wanviput Sanphasitvong leads the longevity medicine curriculum at KMITL, one of the education networks feeding Longevity Grok's physician path.

Insilico Medicine

Builds the discovery tools behind Longevity Grok and runs the Longevity MotherShip.

insilico.com →

ARDD

The Aging Research and Drug Discovery meeting and its wider research network.

agingpharma.org →

Join Longevity Grok

Start on your own today, or ask for early access to the physician and researcher tools.

Available nowI want to use it myselfInstall it on your Grok Bot in about ten minutes. Early accessI'm a physicianThe Clinic team: patient list, visit briefs, clinical evidence. Early accessI'm a researcherThe Lab team, with MotherShip collaboration when invited. ContactPartners and pressCollaborations, media and everything else.

Get in touch

Took Longevity Medicine 101? The Education Hub is the education path into Longevity Grok's physician packages, so mention it in your request. Not yet? Take the free course →

Please don't include any health information. Prefer email? Write to Insilico Medicine at [email protected].